No, since moving Connections to use core WordPress functions to process uploads, image uploading issues have been pretty rare. This was a major change that happened in 8.1. Pretty much if you can upload images using the Media Manager, there should not be any issues uploading images at all since it is basically the same code, just a different destination folder.
Which version did you upgrade from? Any errors or anything being shown? What happens when you try to upload an image? Any additional detail will help, thanks?